A new perspective on adiposity in a naturally obese mammal.

نویسندگان

  • R M Ortiz
  • D P Noren
  • B Litz
  • C L Ortiz
چکیده

Many mammals seasonally reduce body fat due to inherent periods of fasting, which is associated with decreased leptin concentrations. However, no data exist on the correlation between fat mass (FM) and circulating leptin in marine mammals, which have evolved large fat stores as part of their adaptation to periods of prolonged fasting. Therefore, FM was estimated (by tritiated water dilution), and serum leptin and cortisol were measured in 40 northern elephant seal (Mirounga angustirostris) pups early (<1 wk postweaning) and late (6-8 wk postweaning) during their natural, postweaning fast. Body mass (BM) and FM were reduced late; however, percent FM (early: 43.9 +/- 0.5, late: 45.5 +/- 0.5%) and leptin [early: 2.9 +/- 0.1 ng/ml human equivalents (HE), late: 3.0 +/- 0.1 ng/ml HE] did not change. Cortisol increased between early (9.2 +/- 0.5 microg/dl) and late (16.3 +/- 0.9 microg/dl) periods and was significantly and negatively correlated with BM (r = 0.426; P < 0.0001) and FM (r = 0.328; P = 0.003). FM and percent FM were not correlated (P > 0.10) with leptin at either period. The present study suggests that these naturally obese mammals appear to possess a novel cascade for regulating body fat that includes cortisol. The lack of a correlation between leptin and FM may reflect the different functions of fat between terrestrial and marine mammals.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A MAMMAL SPECIES NEW FOR IRAN: GAZELLA GAZELLA PALLAS, 1766 (ARTIODACTYLA: BOVIDAE)

This paper provides evidence for the presence of Gazella gazella on Fmur Island of Iran in the Persian Gulf. The species has not hitherto been reported from Iran. Based on univariate and multivariate analysis of a number of morphological features of the skull including horn length, premaxillae type, shape of nasal bones and skull breadth it is concluded that the Iranian population represents ...

متن کامل

ارتباط تغییرات سطح سرمی لپتین با پروفایل لیپید و شاخص‌های تن سنجی در زنان با درجات مختلف چاقی

Background and Objective: Leptin is a 16 KDa peptide which has a close correlation with adiposity. However, its effect on lipid profile is controversial in human. Therefore, this study was performed to investigate correlation between variations in serum leptin levels with lipid profile and anthropometric indices in women with different grades of obesity. Materials and Methods: The current cross...

متن کامل

First mammal fossil locality from the late Miocene of Zagros, western Iran

A new and the first mammal fossil locality from the Zagros Basin of Iran is reported here. The fossil locality, known as Dimeh, is located in the Lorestan province, west of Iran. The fauna includes abundant bovid cranial remains, mostly representing boselaphines and palaeoryxoids, as well as gazelles and spiral horned antelopes. Hipparionine horses similar to Hippotherium group are also represe...

متن کامل

Dynamics, Stability Analysis and Control of a Mammal-Like Octopod Robot Driven by Different Central Pattern Generators

In this paper, we studied numerically both kinematic and dynamic models of a biologically inspired mammal-like octopod robot walking with a tetrapod gait. Three different nonlinear oscillators were used to drive the robot’s legs working as central pattern generators. In addition, also a new, relatively simple and efficient model was proposed and investigated. The introduced model of the gait ge...

متن کامل

Comparative Evaluation of Iron Deficiency among Obese and Non-obese Children

Background Obese children are at the risk of micronutrient deficiency especially iron deficiency. Given the importance of iron deficiency in this age group and considering the existing discrepancies, present study was performed with the aim of evaluating iron deficiency in obese children. Material and Method This study was conducted, in the form of a case-control study, on 100 children aged...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • American journal of physiology. Endocrinology and metabolism

دوره 281 6  شماره 

صفحات  -

تاریخ انتشار 2001